First a recap of Preseason Week 4 and Regular Season Week 1:
Preseason Week 4
My predictions:
| Away | Home | Away | Home | Favorite | Line | O/U |
| Detroit | Buffalo | 17 | 24 | Buffalo | 7 | 41 |
| NY Jets | Philadelphia | 17 | 20 | Philadelphia | 3 | 37 |
| Atlanta | Baltimore | 20 | 20 | Baltimore | 0 | 40 |
| St. Louis | Kansas City | 20 | 26 | Kansas City | 6 | 46 |
| New England | NY Giants | 24 | 17 | New England | 7 | 41 |
| Cincinnati | Indianapolis | 20 | 27 | Indianapolis | 7 | 47 |
| Jacksonville | Washington | 17 | 24 | Washington | 7 | 41 |
| Carolina | Pittsburgh | 17 | 23 | Pittsburgh | 6 | 40 |
| Tennessee | Green Bay | 20 | 20 | Green Bay | 0 | 40 |
| Chicago | Cleveland | 20 | 17 | Chicago | 3 | 37 |
| Minnesota | Dallas | 17 | 24 | Dallas | 7 | 41 |
| Miami | New Orleans | 20 | 17 | Miami | 3 | 37 |
| Tampa Bay | Houston | 20 | 23 | Houston | 3 | 43 |
| Denver | Arizona | 26 | 27 | Arizona | 1 | 53 |
| San Diego | San Francisco | 27 | 17 | San Diego | 10 | 44 |
| Oakland | Seattle | 16 | 27 | Seattle | 11 | 43 |